Immunicum AB / Fortsatt sträckbänk / Ilixadencel + Opdivo=sant? Är det tänkt att Ilixadencel och opdivo (HCC) skall testas i kombo?

Vidare beviljade amerikanska FDA särläkemedelsstatus (Orphan Drug Designation) för ilixadencel in hepatocellular carcinoma (HCC).

Positiva topline resultat från den slutförda fas I/II studien som undersökt säkerhet och tolerans av ilixadencel hos 18 patienter med avancerad  of Phase I/II Clinical Trial Results of Ilixadencel in Advanced Hepatocellular Carcinoma in Frontiers in Oncology Immunicum AB (publ; IMMU. Receives FDA Orphan Drug Designation for Ilixadencel as a Treatment for Hepatocellular Carcinoma (HCC) Immunicum AB (publ; IMMU. Vidare beviljade amerikanska FDA särläkemedelsstatus (Orphan Drug Designation) för ilixadencel in hepatocellular carcinoma (HCC). Of 17 HCC patients enrolled, 12 patients received ilixadencel at the dose of 10 x cell therapy, immunotherapy, allogeneic, dendritic cells, ilixadencel, sorafenib  tyder på att ilixadencel skulle kunna bidra till att övervinna resistensen mot levercancer (Hepatocellular carcinoma; HCC) behandlats med ilixadencel. Endast  Ilixadencel har hittills uppvisat en konsekvent säkerhetsprofil i studien hepatocellulärt karcinom (HCC), gastrointestinala stromala tumörer  kombinerad behandling med ilixadencel leder till en nästan dubbelt så karcinom (HCC) och gastrointestinala stromala tumörer (GIST) samt i  IMMUNICUM: SÄRLÄKEMEDELSSTATUS FÖR ILIXADENCEL MOT för bolagets kandidat ilixadencel för behandling av levercancer (HCC). the Phase II MERECA trial with ilixadencel delivered a positive surprise.

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RCC, HCC. Overall Strategy. Immune system. Strategy. Stimulate the immune system. Drug Category. Immune stimulate  Jan 21, 2019 Several lines of evidence support immunotherapy in hepatocellular carcinoma ( HCC).

Ilixadencel har hittills uppvisat en konsekvent säkerhetsprofil i studien hepatocellulärt karcinom (HCC), gastrointestinala stromala tumörer 

AB (publ) erhåller särläkemedelsstatus, ODD, från EMA för ilixadencel för för ilixadencel för behandling av hepatocellulärt carcinom (HCC). Positiva topline resultat från den slutförda fas I/II studien som undersökt säkerhet och tolerans av ilixadencel hos 18 patienter med avancerad  of Phase I/II Clinical Trial Results of Ilixadencel in Advanced Hepatocellular Carcinoma in Frontiers in Oncology Immunicum AB (publ; IMMU. Receives FDA Orphan Drug Designation for Ilixadencel as a Treatment for Hepatocellular Carcinoma (HCC) Immunicum AB (publ; IMMU.

May 11, 2020 Immunicum AB has won an FDA RMAT for ilixadencel, its allogeneic hepatocellular carcinoma (HCC) and gastrointestinal stromal tumors 

2018-06-14 2021-01-04 2019-01-21 Hittills har ilixadencel testats i en rad kliniska prövningar i olika solida tumörindikationer inklusive metastaserande njurcancer (mRCC), hepatocellulärt karcinom (HCC), gastrointestinala stromala tumörer (GIST) och i kombination med flera standardbehandlingar av cancer som tyrosinkinashämmare Sutent® (sunitinib) och Stivarga® (regorafenib) och checkpointhämmaren Keytruda® (pembrolizumab). Of 17 HCC patients enrolled, 12 patients received ilixadencel at the dose of 10 × 10⁶ cells (six as monotherapy and six in combination with sorafenib), and five received ilixadencel at the dose we assessed ilixadencel as a single agent and combined with sorafenib in advanced HCC. Of 17 HCC patients enrolled, 12 patients received ilixadencel at the dose of 10 × 106 cells (six as monotherapy and six in combination with sorafenib), and five received ilixadencel at the dose of 20 × … Press Release 21 January 2019 Immunicum AB (publ) Announces Publication of Phase I/II Clinical Trial Results of Ilixadencel in Advanced Hepatocellular Carcinoma in Frontiers in Oncology Immunicum AB (publ; IMMU.ST) announced today that the final data analysis from the exploratory clinical study of ilixadencel in patients with advanced hepatocellular carcinoma (HCC) has been published in the Here, we assessed ilixadencel as a single agent and combined with sorafenib in advanced HCC. Of 17 HCC patients enrolled, 12 patients received ilixadencel at the dose of 10 x 10 6 cells (six as monotherapy and six in combination with sorafenib), and five received ilixadencel at the dose of … 2021-01-04 Ilixadencel is an off-the-shelf cell-based cancer immunotherapy. In addition to being assessed as treatment of patients with mRCC, it has also been studied in hepatocellular carcinoma and gastrointestinal stromal tumors in combination with the tyrosine kinase inhibitor sunitinib, the multikinase inhibitor regorafenib (Stivarga), and the checkpoint inhibitor pembrolizumab (Keytruda). To-date ilixadencel has been tested in a range of clinical trials in various solid tumor indications including metastatic Renal Cell Carcinoma (mRCC), hepatocellular carcinoma (HCC) and gastrointestinal stromal tumors (GIST) and in combination with several standard-of-care cancer therapies such as the tyrosine kinase inhibitors Sutent® (sunitinib) and Stivarga® (regorafenib), and the checkpoint inhibitor … 2020-05-11 To-date ilixadencel has been tested in a range of clinical trials in various solid tumor indications including metastatic Renal Cell Carcinoma (mRCC), hepatocellular carcinoma (HCC) and Press Release 31 December 2020 Immunicum AB (publ) Receives FDA Orphan Drug Designation for Ilixadencel as a Treatment for Hepatocellular Carcinoma (HCC) Immunicum AB (publ; IMMU.ST) announced today that it has received Orphan Drug Designation (ODD) from the U.S. Food and Drug Administration (FDA) for the Company’s lead candidate, ilixadencel, a cell-based, off-the-shelf immune … Press Release 28 September 2017. Immunicum AB (publ) Announces Completion of HCC Phase I/II Clinical Study --Topline Safety and Immune Response Data Support Continued Development of Ilixadencel in Liver Cancer-- 2018-06-07 Immunicum AB (publ) Receives FDA Orphan Drug Designation for Ilixadencel as a Treatment for Hepatocellular Carcinoma (HCC) Immunicum AB (publ; IMMU.ST) announced today that … 31.12.2020 - Press Release 31 December 2020 Immunicum AB (publ) Receives FDA Orphan Drug Designation for Ilixadencel as a Treatment for Hepatocellular Carcinoma (HCC… Immunicum AB (publ) Receives FDA Orphan Drug Designation for Ilixadencel as a Treatment for Hepatocellular Carcinoma (HCC) Immunicum AB (publ; IMMU.ST) announced today that it has received Orphan Drug Designation (ODD) from the U.S. Food and Drug Administration (FDA) for the Company’s lead candidate, ilixadencel, a cell-based, off-the-shelf immune primer, for the treatment of … Press Release. 28 September 2017.

Immunicum’s H120 operating loss was SEK59.0m vs SEK62.3m a year ago, slightly lower as the MERECA study ended in around mid-2019. Press Release 31 December 2020 Immunicum AB Receives FDA Orphan Drug Designation for Ilixadencel as a Treatment for Hepatocellular Carcinoma Immunicum AB announced today that it has received | … Hittills har ilixadencel testats i en rad kliniska prövningar i olika solida tumörindikationer inklusive metastaserande njurcancer (mRCC), hepatocellulärt carcinom (HCC) och gastrointestinal stromacellstumör (GIST) samt i kombination med olika typer av standardbehandling som tyrosinkinashämmarna Sutent® (sunitinib) och Stivarga® (regorafenib) och checkpointhämmaren … Press Release 31 December 2020Immunicum AB (publ) Receives FDA Orphan Drug Designation for Ilixadencel as a Treatment for Hepatocellular Carcinoma (HCC) Immunicum AB (publ; IMMU.ST) announced today that it has received Orphan Drug Designation (ODD) from the U.S. Food and Drug Administration (FDA) for the Company’s lead candidate, ilixadencel, a cell-based, off-the-shelf immune … Immunicum AB (publ), First North Premier: (IMMU.ST), ett bioteknikbolag som utvecklar nya immunaktiverande cancerbehandlingar för ett antal solida tumörer, offentliggör idag positiva topline resultat från den slutförda fas I/II studien som undersökt säkerhet och tolerans av ilixadencel, Immunicums ledande läkemedelskandidat, hos 18 patienter med avancerad levercancer (HCC). Immunicum erhöll särläkemedelsstatus, Orphan Drug Designation, från FDA för ilixadencel för behandling av levercancer, specifikt hepatocellular carcinoma (HCC). COVID-19 Immunicum har hittills inte haft någon väsentlig påverkan på verksamheten på grund av covid-19-pandemin.
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Vidare beviljade amerikanska FDA särläkemedelsstatus (Orphan Drug Designation) för ilixadencel in hepatocellular carcinoma (HCC). Vidare har ilixadencel utvecklats enligt plan i de pågående kliniska studierna.

Ilixadencel: an off-the-shelf  Immunicums fas II-studie MERECA, som testar ilixadencel i patienter med driver nu tre egna studier inom cancerindikationerna: mRCC, HCC och GIST.
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Hittills har ilixadencel testats i en rad kliniska prövningar i olika solida tumörindikationer inklusive metastaserande njurcancer (mRCC), hepatocellulärt carcinom (HCC) och gastrointestinal

Strategy. Stimulate the immune system. Drug Category.

Immunicum AB (publ) erhåller särläkemedelsstatus, ODD, från FDA för ilixadencel för behandling av levercancer. Publicerad: 2020-12-31 (GlobeNewswire) Immunicum AB (publ) Receives FDA Orphan Drug Designation for Ilixadencel as a Treatment for Hepatocellular Carcinoma (HCC…

Gastric adenocarcinoma. Non-small cell lung cancer. Gastrointestinal stromal tumors.

Its active ingredient is activated allogeneic dendritic cells, derived Here we present preclinical mode of action data, CMC and regulatory data, as well as initial clinical data on ilixadencel. This cell-based drug product is an off-the-shelf immune primer, consisting of pro-inflammatory allogeneic DCs secreting high amounts of pro-inflammatory chemokines and cytokines at the time of intratumoral administration. HCC Childcare Tuition Payment Pay Online for Health Sciences Application, Testing, Other Fees Pay Online for Workforce, Law Enforcement, Fire Fighting, EMS/Paramedic Background Check Fees The active substance ilixadencel (INN) is composed of monocyte-derived dendritic cells (MoDCs) that have been stimulated with a combination of activating factors (R848, Poly I:C and IFN-γ) ex vivo, resulting in a residual production of desirable pro-inflammatory factors (such as TNF-α, IL-1β and MIP-1β and also high amounts of IL-12p70 and RANTES) and expression of co-stimulatory surface molecules (such as CD86) at the time of administration. -- Median Overall Survival (OS) for the ilixadencel combination treatment group has been reached at 35.6 months, as compared to 25.3 months for the sunitinib control group, indicating a potential To date, ilixadencel has been tested in a range of clinical trials for various solid tumor indications including mRCC, hepatocellular carcinoma (HCC), and gastrointestinal stromal tumors (GIST). Of 17 HCC patients enrolled, 12 patients received ilixadencel at the dose of 10 × 10⁶ cells (six as monotherapy and six in combination with sorafenib), and five received ilixadencel at the dose To-date ilixadencel has been tested in a range of clinical trials in various solid tumor indications including metastatic Renal Cell Carcinoma (mRCC), hepatocellular carcinoma (HCC) and gastrointestinal stromal tumors (GIST) and in combination with several standard-of-care cancer therapies such as the tyrosine kinase inhibitors Sutent® (sunitinib) and Stivarga® (regorafenib), and the checkpoint inhibitor Keytruda® (pembrolizumab). Beyond the safety profile, the immunological data confirm our mechanism of action and support our plans to move ilixadencel forward in HCC, an important part of our clinical development strategy," said Carlos de Sousa, MD, CEO of Immunicum.